Fisetin in Alzheimer’s: Single-Cell Study Merges Genomics and TCM
A research team from Guangxi Medical University, led by Dr. Zou Donghua, published groundbreaking findings in Phytomedicine. Using single-nucleus RNA sequencing (snRNA-seq) and network pharmacology, they identified fisetin—a flavonoid found in strawberries and apples—as a potent inhibitor of neuroinflammation in Alzheimer’s Disease (AD). This interdisciplinary approach combines cutting-edge genomics with traditional Chinese medicine (TCM), offering new hope for AD treatment.
Fisetin: The Underdog Anti-Aging Compound Making Waves in Longevity and Skincare
Fisetin’s journey mirrors compounds like resveratrol and NMN—longevity darlings that later crossed into cosmetics. Its ability to target inflammaging and senescent cells positions it as a compelling "cellular detox" candidate. For brands willing to tackle formulation hurdles, Fisetin offers a fresh narrative: a misunderstood plant extract with hard science and quirky appeal. As one researcher quipped, "Skincare thrives on stories. Fisetin’s got more chapters than most."
Breakthrough in Berberine Biosynthesis Reveals Convergent Evolution
A landmark study in Science Advances (2024) by researchers from Northeast Forestry University and Chengdu University of TCM revealed a novel biosynthetic pathway in this plant, diverging from known routes in Coptis.
Berberine Breakthrough: New Clinical Findings Unveil Multifaceted Health Benefits
Berberine’s multitarget pharmacology—ranging from lipid modulation to insulin sensitization—positions it as a cost-effective alternative for metabolic and cardiovascular diseases. With China’s research breakthroughs validating its molecular mechanisms, BBR offers a sustainable solution for global health challenges like diabetes and atherosclerosis. Ongoing studies aim to optimize personalized dosing through genetic profiling, promising broader clinical adoption.
Berberine Unveiled: The Ancient Botanical Powering Modern Fitness and Metabolic Health
Berberine, a potent bioactive compound extracted from plants like Berberis vulgaris, Berberis Aristata, is emerging as a game-changer in sports nutrition and metabolic wellness. Traditionally used in Ayurvedic and Chinese medicine, this golden-hued alkaloid is now backed by science for its dual role in enhancing exercise performance and regulating blood sugar.
Berberine Emerges as a Multi-Organ Protector: New Research Highlights Its Therapeutic Versatility
Berberine, a bioactive compound derived from plants like goldenseal and barberry, is gaining attention for its broad-spectrum protective effects on vital organs, according to recent studies. Researchers are uncovering its mechanisms in combating liver disease, gastrointestinal disorders, kidney damage, and more—positioning it as a promising natural therapeutic agent.
Can Eating Mushrooms Extend Lifespan by 20%? Cell Study Unveils Ergothioneine’s Remarkable Anti-Aging Power via NAD+ Boosting
While antioxidants dominate the anti-aging scene, ergothioneine (ET)—a sulfur-containing amino acid—has emerged as a dual-purpose marvel, captivating both skincare enthusiasts and longevity researchers. Recently, a groundbreaking study in Cell Metabolism revealed that ET’s benefits go far beyond its antioxidant prowess: it boosts NAD+ levels by twofold, rivaling NMN, a popular longevity compound.
New CoQ10 Rice Variety Developed by Chen Xiaoya’s Team in Cell
Chen Xiaoya's team creates rice that produces CoQ10, improving nutrition with a sustainable, cost-effective source of the essential nutrient.
Berberine: An Ancient Remedy Finds Its Calling in Gut Health
Berberine, a natural alkaloid extracted from plants like berberis aristata or Berberis vulgaris or Phellodendron chinense, has been a cornerstone of traditional Chinese medicine for centuries, known for its characteristic bitterness. Once considered an underutilized "minor player" in modern medicine, recent research has unveiled its profound effects on gut health, metabolism, and various chronic diseases. This breakthrough has placed berberine in the spotlight as a powerful natural therapeutic agent.
Discovery of EIF2AK2 as a Direct Key Target for Berberine’s Anti-Inflammatory Effects
A groundbreaking study recently published in Acta Pharmaceutica Sinica B (IF 14.5) uncovers the key mechanism behind berberine's (BBR) anti-inflammatory effects. This research identifies EIF2AK2 (also known as PKR) as a direct and crucial target of BBR, shedding light on how this widely regarded "miracle drug" exerts its therapeutic effects.